Mechanism and regulation of mitotic poisons.

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons.

The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) Cancer Res 67:160-166]. However, the prevalence and consequences of Mad1 overexpression are curren...

a tripartite model of efl teachers attributions, burnout, and ‎self-regulation: towards the prospects of effective teaching

همطالعه حاضر به ارائه مدلی برای آموزش موثر زبان انگلیسی ‏می پردازد. مدل حاضر از سه عامل تاثیر گذار در کارایی ‏تدریس معلمان زبان انگلیسی بهره می برد. این سه عامل شامل ‏سبکهای اسنادی، خود تنطیمی و فرسودگی شغلی معلمان ایرانی ‏زبان انگلیسی می باشد. رساله مورد نظر درچهار فاز طراحی ‏شده است: فاز اول شامل طراحی و رواسازی پرسشنامه سبکهای ‏اسنادی معلمان زبان انگلیسی و فاز دوم شامل استفاده از ‏این پرسشنا...

Mechanism of regulation of protein Kinase Aurora A in response to Mitotic DNA damage

Mitosis is a highly ordered collection of events that ensures that the duplicated genome is distributed to the daughter cells equally. A failure to do so results in loss of genetic information leading to aneuploidy, a condition frequently associated with cancer. Several mitotic kinases are targets of the DNA damage checkpoint, among which Cdk1, Aurora A and Plk1 are the most significant. Aurora...

Cholera and Fever Poisons

Microtubule-dependent regulation of mitotic protein degradation.

Accurate cell division depends on tightly regulated ubiquitylation events catalyzed by the anaphase-promoting complex (APC/C). Among its many substrates, the APC/C triggers the degradation of proteins that stabilize the mitotic spindle, and loss or accumulation of such spindle assembly factors can result in aneuploidy and cancer. Although critical for cell division, it has remained poorly under...